8. Unusually Itchy Skin that Disrupts Sleep
Severe, unrelenting skin itching—medically termed pruritus—frequently accompanies liver disease. When your liver fails to properly filter toxins and process bile, bile salts aggressively accumulate just beneath the surface of your skin. This buildup triggers intense itching that typical moisturizing lotions or topical creams cannot soothe. The itching often targets the palms of your hands and the soles of your feet, and it notoriously worsens during the late evening and nighttime hours. Consequently, this persistent discomfort drastically disrupts your sleep patterns, compounding the profound fatigue you already experience from the underlying liver inflammation.
