Environmental factors that increase the risk of side effects
Diet can influence how certain medicines react. Numerous medications have dietary interactions. For instance, tyramine-containing foods and MAOI antidepressants, atorvastatin with grapefruit, warfarin and green leafy vegetables, natural black licorice and lithium, salt and potassium supplements, and ACE inhibitors.
Some medication’s potential for side effects can be increased by dehydration. NSAIDs, metformin, ACE inhibitors, and diuretics are a few medications that should not be taken by someone who is dehydrated.
Alcohol can make several adverse effects worse, including sleepiness, disorientation, blood pressure abnormalities, aberrant behavior, respiratory depression, nausea, and vomiting.